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1. (WO2018005781) PROCESS OF PREPARING A PEPTIDE EPOXYKETONE IMMUNOPROTEASOME INHIBITOR, AND PRECURSORS THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/005781    International Application No.:    PCT/US2017/039975
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
C07D 295/15 (2006.01), C07D 303/12 (2006.01), C07D 303/46 (2006.01), C07C 69/612 (2006.01)
Applicants: KEZAR LIFE SCIENCES [US/US]; 300 Utah Ave, Suite 105 South San Francisco, CA 94080 (US)
Inventors: JOHNSON, Henry; (US).
DALZIEL, Sean; (US).
MCMINN, Dustin; (US)
Agent: BERKOWSKI, Kimberly L.; (US)
Priority Data:
62/356,178 29.06.2016 US
Title (EN) PROCESS OF PREPARING A PEPTIDE EPOXYKETONE IMMUNOPROTEASOME INHIBITOR, AND PRECURSORS THEREOF
(FR) PROCÉDÉ DE PRÉPARATION D'INHIBITEUR D'IMMUNOPROTÉASOME DE PEPTIDE ÉPOXYCÉTONE ET PRÉCURSEURS ASSOCIÉS
Abstract: front page image
(EN)Disclosed herein are methods for preparing [(2S,3R)-N-[(2S)-3-(cyclopent- 1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound "G"): and precursors thereof.
(FR)L'invention concerne des procédés de préparation de [(2S,3R)-N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-méthyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-méthoxyphényl)-2-[(2S)-2-[2-(morpholin-4-yl)acétamido]propanamido]propanamide (composé "G"); ainsi que des précurseurs associés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)