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1. (WO2018005781) PROCESS OF PREPARING A PEPTIDE EPOXYKETONE IMMUNOPROTEASOME INHIBITOR, AND PRECURSORS THEREOF

Pub. No.:    WO/2018/005781    International Application No.:    PCT/US2017/039975
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Fri Jun 30 01:59:59 CEST 2017
IPC: C07D 295/15
C07D 303/12
C07D 303/46
C07C 69/612
Applicants: KEZAR LIFE SCIENCES
Inventors: JOHNSON, Henry
DALZIEL, Sean
MCMINN, Dustin
Title: PROCESS OF PREPARING A PEPTIDE EPOXYKETONE IMMUNOPROTEASOME INHIBITOR, AND PRECURSORS THEREOF
Abstract:
Disclosed herein are methods for preparing [(2S,3R)-N-[(2S)-3-(cyclopent- 1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound "G"): and precursors thereof.