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1. (WO2018005720) METHOD OF DETERMINING THE MOLECULAR BINDING BETWEEN LIBRARIES OF MOLECULES
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Pub. No.: WO/2018/005720 International Application No.: PCT/US2017/039862
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
C12Q 1/68 (2018.01) ,C07K 16/00 (2006.01) ,C40B 30/04 (2006.01) ,C40B 40/08 (2006.01) ,C40B 50/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30
Methods of screening libraries
04
by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
06
Libraries containing nucleotides or polynucleotides, or derivatives thereof
08
Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
50
Methods of creating libraries, e.g. combinatorial synthesis
06
Biochemical methods, e.g. using enzymes or whole viable micro-organisms
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138, US
Inventors:
GRISWOLD, Kettner John Frederick; US
FANG, Neng; US
Agent:
IWANICKI, John P.; US
Priority Data:
62/356,81130.06.2016US
Title (EN) METHOD OF DETERMINING THE MOLECULAR BINDING BETWEEN LIBRARIES OF MOLECULES
(FR) PROCÉDÉ DE DÉTERMINATION DE LA LIAISON MOLÉCULAIRE ENTRE DES BANQUES DE MOLÉCULES
Abstract:
(EN) A method for determining the molecular binding between a target molecule library and a binder molecule library is provided including contacting the target molecule library comprising a plurality of mRNA-protein conjugates with the binder molecule library comprising a plurality of mRNA-protein conjugates under conditions where one or more proteins in the target library bind to one or more proteins in the binder library, and determining the molecular binding of the target and binder protein pairs by determining the sequences of the mRNAs conjugated to the target and binder protein pairs.
(FR) L'invention porte sur un procédé visant à déterminer la liaison moléculaire entre une banque cible de molécules et une banque de molécules de liaison, et consistant à mettre en contact la banque cible de molécules comprenant une pluralité de conjugués ARNm-protéines avec la banque de molécules de liaison comprenant une pluralité de conjugués ARNm-protéines dans des conditions où une ou plusieurs protéines de la banque cible se lient à une ou plusieurs protéines de la banque de liants, et déterminer la liaison moléculaire des paires de protéines cibles et de liaison en déterminant les séquences des ARNm conjugués aux paires de protéines cibles et de liaison.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)