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1. (WO2018005720) METHOD OF DETERMINING THE MOLECULAR BINDING BETWEEN LIBRARIES OF MOLECULES

Pub. No.:    WO/2018/005720    International Application No.:    PCT/US2017/039862
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Fri Jun 30 01:59:59 CEST 2017
IPC: C12Q 1/68
C07K 16/00
C40B 30/04
C40B 40/08
C40B 50/06
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors: GRISWOLD, Kettner John Frederick
FANG, Neng
Title: METHOD OF DETERMINING THE MOLECULAR BINDING BETWEEN LIBRARIES OF MOLECULES
Abstract:
A method for determining the molecular binding between a target molecule library and a binder molecule library is provided including contacting the target molecule library comprising a plurality of mRNA-protein conjugates with the binder molecule library comprising a plurality of mRNA-protein conjugates under conditions where one or more proteins in the target library bind to one or more proteins in the binder library, and determining the molecular binding of the target and binder protein pairs by determining the sequences of the mRNAs conjugated to the target and binder protein pairs.