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1. (WO2018005710) DEVICES AND METHODS FOR THE DETECTION OF MOLECULES USING A FLOW CELL

Pub. No.:    WO/2018/005710    International Application No.:    PCT/US2017/039844
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Thu Jun 29 01:59:59 CEST 2017
IPC: C12Q 1/68
C12P 19/34
G01N 33/53
Applicants: CLICK DIAGNOSTICS, INC.
ROY, Shaunak
Inventors: ROY, Shaunak
ANDREYEV, Boris
BHATIA, Rajinder K.
BRIONES, Victor
CAO, Phoebe
CHING, Jesus
CIOPYK, Brian
DE LA ZERDA, Adam
HONG, Jonathan H.
HUANG, Helen
KELLY, Colin
LAM, Adrienne C.
LONEY, Gregory C.
MCSHEERY, Danielle
MORAVICK, Keith E.
REVILLA, Valeria
SWENSON, David D.
Title: DEVICES AND METHODS FOR THE DETECTION OF MOLECULES USING A FLOW CELL
Abstract:
A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.