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1. (WO2018005697) ANTIBODIES SPECIFIC TO SONIC HEDGEHOG AND METHOD OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/005697 International Application No.: PCT/US2017/039831
Publication Date: 04.01.2018 International Filing Date: 28.06.2017
IPC:
A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,C07K 16/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607, US
Inventors: JABLONS, David M.; US
TOLANI, Bhairavi; US
HE, Biao; US
GIROUX-LEPRIEUR, Etienne; FR
Agent: NG, Rudy J.; US
Priority Data:
62/356,27629.06.2016US
Title (EN) ANTIBODIES SPECIFIC TO SONIC HEDGEHOG AND METHOD OF USE THEREOF
(FR) ANTICORPS SPÉCIFIQUES DE LA PROTÉINE SONIC HEDGEHOG ET PROCÉDÉ D'UTILISATION ASSOCIÉ
Abstract:
(EN) Antibodies that specifically bind to a Sonic Hedgehog (Shh) polypeptide, or an antigen binding fragment thereof, are provided. Also provided are methods of treating an individual for cancer using the Shh polypeptide antibodies. Methods of analyzing a tissue sample for cell-surface expression of a full-length Shh polypeptide are also provided.
(FR) L'invention concerne des anticorps qui se lient spécifiquement à un polypeptide de la protéine Sonic Hedgehog (Shh) ou un fragment de liaison à l'antigène de ceux-ci. L'invention concerne également des procédés de traitement du cancer chez un individu à l'aide des anticorps contre un polypeptide de Shh. L'invention concerne également des procédés d'analyse d'un échantillon de tissu pour déterminer l'expression de surface cellulaire d'un polypeptide de Shh de longueur totale.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)