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1. (WO2018005695) USE OF NEUROKININ-1 ANTAGONISTS TO TREAT A VARIETY OF PRURITIC CONDITIONS
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Pub. No.: WO/2018/005695 International Application No.: PCT/US2017/039829
Publication Date: 04.01.2018 International Filing Date: 28.06.2017
IPC:
A61K 31/4035 (2006.01) ,A61K 45/06 (2006.01) ,A61P 17/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
4035
Isoindoles, e.g. phthalimide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
04
Antipruritics
Applicants: MENLO THERAPEUTICS INC.[US/US]; 4085 Campbell Avenue, Suite 200 Menlo Park, CA 94025, US
Inventors: BASTA, Steven; US
JOING, Mark; US
ZHANG, Xiaoming; US
KWON, Paul; US
Agent: SILVERMAN, Lisa, N.; US
Priority Data:
62/356,26429.06.2016US
62/356,27129.06.2016US
62/356,28029.06.2016US
62/356,28629.06.2016US
62/356,29129.06.2016US
62/356,29429.06.2016US
62/356,30129.06.2016US
Title (EN) USE OF NEUROKININ-1 ANTAGONISTS TO TREAT A VARIETY OF PRURITIC CONDITIONS
(FR) UTILISATION D’ANTAGONISTES DE NEUROKININE-1 DANS LE TRAITEMENT D’UNE VARIÉTÉ D’ÉTATS PRURITIQUES
Abstract:
(EN) The disclosure relates to the use of neurokinin-1 (NK-1) antagonists, such as serlopitant, in treating acute or chronic pruritus associated with a variety of medical conditions, including dermatitis/eczema, psoriasis, prurigo, urticaria, cutaneous T-cell lymphoma, epidermolysis bullosa, bums and hepato-biliary diseases, or/and treating the medical conditions themselves. One or more additional antipruritic or therapeutic agents can optionally be used in combination with an NK-1 antagonist to treat acute or chronic pruritus associated with a medical condition or/and the medical condition itself.
(FR) La présente invention concerne l'utilisation d'antagonistes de neurokinine-1 (NK-1), tels que le serlopitant, dans le traitement du prurit aigu ou chronique associé à une variété d'états pathologiques, y compris dermatite/eczéma, psoriasis, prurit, urticaire, lymphome cutané à cellules T, épidermolyse bulleuse, brûlures et maladies hépatobiliaires, et/ou le traitement des états pathologiques eux-mêmes. Un ou plusieurs agents supplémentaires antiprurigineux ou thérapeutiques peuvent facultativement être utilisés en combinaison avec un antagoniste de NK-1 pour traiter un prurit aigu ou chronique associé à un état pathologique et/ou l'état pathologique lui-même.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)