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1. (WO2018005647) SYSTEMS AND METHODS FOR HIGH-THROUGHPUT CELL SCREENING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/005647 International Application No.: PCT/US2017/039756
Publication Date: 04.01.2018 International Filing Date: 28.06.2017
IPC:
B01L 3/00 (2006.01) ,B01L 99/00 (2010.01) ,B81C 1/00 (2006.01) ,B81C 3/00 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
99
Subject matter not provided for in other groups of this subclass
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
C
PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICRO-STRUCTURAL DEVICES OR SYSTEMS
1
Manufacture or treatment of devices or systems in or on a substrate
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
C
PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICRO-STRUCTURAL DEVICES OR SYSTEMS
3
Assembling of devices or systems from individually processed components
Applicants: GEORGIA TECH RESEARCH CORPORATION[US/US]; 505 Tenth St., NW Atlanta, Georgia 30332, US
Inventors: SARIOGLU, Ali, Fatih; US
CHU, Chia-Heng; US
LIU, Ruxiu; US
OZKAYA-AHMADOV, Tevhide; US
Agent: SCHNEIDER, Ryan, A.; US
CLOSE, Christopher, C.; US
HENSLEY, Micah, B.; US
Priority Data:
62/355,74528.06.2016US
Title (EN) SYSTEMS AND METHODS FOR HIGH-THROUGHPUT CELL SCREENING
(FR) SYSTÈMES ET PROCÉDÉS DE CRIBLAGE CELLULAIRE À HAUTT DÉBIT
Abstract:
(EN) The disclosed technology includes devices and methods for detecting rare cells in whole blood samples using a microfluidic device. Such devices include a housing with a microfluidic chamber having first and second microfluidic layers, each microfluidic layer having an array of microscale structure. Other disclosed devices also include a housing including a chemically functionalized hydrogel matrix and a pump connected to the housing. Disclosed methods include constructing, with an additive manufacturing device, a microfluidic device having a microfluidic chamber, removing, by a thermal release process, at least some of the sacrificial support material deposited by the additive manufacturing device, and chemically functionalizing at least a portion of the microfluidic chamber. Other disclosed methods include chemically functionalizing a hydrogel matrix and connecting the chemically functionalized hydrogel matrix to a pump.
(FR) La technologie décrite comprend des dispositifs et des procédés pour détecter des cellules rares dans des échantillons entiers de sang à l'aide d'un dispositif microfluidique. De tels dispositifs comprennent un boîtier avec une chambre microfluidique ayant des première et seconde couches microfluidiques, chaque couche microfluidique ayant un réseau de structures de petite échelle. D'autres dispositifs décrits comprennent également un boîtier comprenant une matrice d'hydrogel fonctionnalisée chimiquement et une pompe reliée au boîtier. Les procédés décrits comprennent la construction, avec un dispositif de fabrication d'additif, d'un dispositif microfluidique ayant une chambre microfluidique, l'élimination, par un procédé de libération thermique, d'au moins une partie du matériau de support sacrificiel déposé par le dispositif de fabrication d'additif, et à fonctionnaliser chimiquement au moins une partie de la chambre microfluidique. D'autres procédés décrits comprennent la fonctionnalisation chimique d'une matrice d'hydrogel et la liaison de la matrice d'hydrogel fonctionnalisée chimiquement à une pompe.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)