Search International and National Patent Collections

1. (WO2018005589) ALTERING EXPRESSION OF GENE PRODUCTS IN PLANTS THROUGH TARGETED INSERTION OF NUCLEIC ACID SEQUENCES

Pub. No.:    WO/2018/005589    International Application No.:    PCT/US2017/039641
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Thu Jun 29 01:59:59 CEST 2017
IPC: C12N 15/82
A01H 5/00
Applicants: CELLECTIS
Inventors: BALTES, Nicholas
Title: ALTERING EXPRESSION OF GENE PRODUCTS IN PLANTS THROUGH TARGETED INSERTION OF NUCLEIC ACID SEQUENCES
Abstract:
Materials and methods for changing expression of a gene product in a plant are provided, and in an embodiment for creating herbicide tolerant plants are described herein. The methods provide for inserting into a plant genome, at a different locus than an endogenous gene, a genomic or coding sequence of the gene, which may be modified, into a genetic location that is different from the endogenous gene and where there is a desired transcriptional activity. The methods described herein can include the targeted insertion of an endogenous 5-enolpyruvylshikimate-3-phosphate synthase gene into a genomic locus that enables sufficient expression to confer herbicide tolerance.