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1. (WO2018005558) SELF-ASSEMBLING INSECT FERRITIN NANOPARTICLES FOR DISPLAY OF CO-ASSEMBLED TRIMERIC ANTIGENS

Pub. No.:    WO/2018/005558    International Application No.:    PCT/US2017/039595
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Wed Jun 28 01:59:59 CEST 2017
IPC: A61K 39/12
A61K 39/295
C07K 14/11
C07K 14/16
C07K 14/435
Applicants: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors: KWONG, Peter
GEORGIEV, Ivelin
JOYCE, Michael, Gordon
KANEKIYO, Masaru
DRUZ, Aliaksandr
BAXA, Ulrich
VAN GALELN, Joseph
CHEN, Rita
CHENG, Cheng
MASCOLA, John
TSYBOVSKY, Yaroslav
YANG, Yongping
THOMAS, Paul
GRAHAM, Barney
Title: SELF-ASSEMBLING INSECT FERRITIN NANOPARTICLES FOR DISPLAY OF CO-ASSEMBLED TRIMERIC ANTIGENS
Abstract:
Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.