WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018005546) ENGINEERED CARDIOMYOCYTES AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/005546    International Application No.:    PCT/US2017/039576
Publication Date: 04.01.2018 International Filing Date: 27.06.2017
IPC:
A61K 35/34 (2015.01), C12N 5/0735 (2010.01), C12N 5/16 (2006.01)
Applicants: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE [US/US]; 1650 Owens Street San Francisco, CA 94158 (US)
Inventors: SRIVASTAVA, Deepak; (US).
ANG, Yen-Sin; (US)
Agent: DEVORE, Dianna, L.; (US)
Priority Data:
62/354,937 27.06.2016 US
Title (EN) ENGINEERED CARDIOMYOCYTES AND USES THEREOF
(FR) GLYCOPROTÉINES MODIFIÉES.
Abstract: front page image
(EN)The present disclosure provides the development of engineered cardiomyocytes having mutations in transcription factor involved in vivo with cardiac development and/or function. These cell populations comprise mutations that are associated with deleterious effects in vivo in mammals. The mutations of the engineered cardiomyocytes of the disclosure thus are rationally designed based on demonstrated physiological effects in mammals, e.g., mice or humans.
(FR)L'invention porte sur le développement de cardiomyocytes modifiés, ayant des mutations dans le facteur de transcription impliqué avec le développement et/ou la fonction cardiaque in vivo. Ces populations de cellules comprennent des mutations qui sont associées aux effets délétères in vivo chez les mammifères. Les mutations des cadiomyocytes sont fait à partir des effets physiologiques sur les mammifères, ex: souris ou humain.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)