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1. (WO2018005518) PHARMACEUTICAL PREPARATION FOR DELIVERY OF PEPTIDES AND PROTEINS
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Pub. No.: WO/2018/005518 International Application No.: PCT/US2017/039535
Publication Date: 04.01.2018 International Filing Date: 27.06.2017
IPC:
A61K 9/50 (2006.01) ,A61K 9/52 (2006.01) ,A61K 9/66 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
52
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
52
Sustained or differential release type
66
containing emulsions, dispersions or solutions
Applicants:
TAMARISK TECHNOLOGIES GROUP LLC [US/US]; 530 E. Los Angeles Ave. #115-201 Moorpark, California 93021, US
Inventors:
CARDONA, Claudia M.; US
KETNER, Mark Ennis; US
CHINTA, Dakshinamurthy Devanga; US
SAHI, Carl R.; US
POLIDORO, John M.; US
GLADDEN, James-Thomas Marion; US
Agent:
COOK, Crissa A.; US
Priority Data:
62/355,07227.06.2016US
Title (EN) PHARMACEUTICAL PREPARATION FOR DELIVERY OF PEPTIDES AND PROTEINS
(FR) PRÉPARATION PHARMACEUTIQUE POUR L'ADMINISTRATION DE PEPTIDES ET DE PROTÉINES
Abstract:
(EN) Provided herein is a composite microparticle for oral delivery of an active agent to a subject. The microparticles are general in the form of self-sustaining bodies comprising a crosslinked polymer matrix and a plurality of emulsion droplets distributed throughout. The active agent is encapsulated in the emulsion droplets. A plurality of delivery enhancing moieties are presented on the exterior surface of said self-sustaining body and/or on the emulsion droplets. The microparticle is resistant to enteric degradation and will localize in the gastrointestinal tract of the subject without crossing the intestinal mucosa into the intestinal bloodstream.
(FR) L'invention concerne une microparticule composite pour l'administration par voie orale d'un agent actif à un sujet. Les microparticules se présentent généralement sous la forme de corps autonomes comprenant une matrice polymère réticulée et de multiples gouttelettes d'émulsion réparties dans l'ensemble de la matrice. L'agent actif est encapsulé dans les gouttelettes d'émulsion. Différentes entités permettant d'améliorer l'administration sont présentées au niveau de la surface extérieure dudit corps autonome et/ou en surface des gouttelettes d'émulsion. La microparticule est résistante à la dégradation entérique et peut se localiser dans le tractus gastro-intestinal du sujet sans traverser la muqueuse intestinale et passer dans la circulation sanguine intestinale.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)