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1. (WO2018005435) 4,6-DIAMINOQUINAZOLINES AS COT MODULATORS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/005435    International Application No.:    PCT/US2017/039418
Publication Date: 04.01.2018 International Filing Date: 27.06.2017
IPC:
C07D 403/12 (2006.01), C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 417/14 (2006.01), A61K 31/517 (2006.01), A61P 35/00 (2006.01), A61P 29/00 (2006.01), A61P 3/10 (2006.01)
Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive Foster City, CA 94404 (US)
Inventors: BALAN, Gayatri; (US).
CHOU, Chien-Hung; (US).
KIM, Musong; (US).
KIRSCHBERG, Thorsten A.; (US).
LINK, John O.; (US).
PHILLIPS, Gary; (US).
SAITO, Roland D.; (US).
SQUIRES, Neil H.; (US).
TAYLOR, James G.; (US).
WATKINS, William J.; (US).
WRIGHT, Nathan E.; (US)
Agent: CAPPS, Kevin J.; (US).
AMIRGHOLIZADEH, Tashica W.; (US).
BARRON, Briana R.; (US).
BOSS, Brandon; (US).
DAMMANN, Yu-Ming; (US).
EDWARDS, Mary J.; (US).
GINAH, Francis O.; (US).
HARTRUM, J. Elin; (US).
HUTCHISON, Andrea; (US).
ISSAC, Roy; (US).
LECHNER, Jolie D.; (US).
LEWIS, Brian; (US).
LO, Karen; (US).
MARQUART, Timothy A.; (US).
MORGAN, Lorie Ann; (US).
POLSTER, Philip B.; (US).
RICE, Katharine R.; (US).
ROZSNYAI, Lawrence F.; (US).
SILVER, Joel; (US).
TATE, Daniel S.; (US)
Priority Data:
62/356,926 30.06.2016 US
Title (EN) 4,6-DIAMINOQUINAZOLINES AS COT MODULATORS AND METHODS OF USE THEREOF
(FR) 4,6-DIAMINOQUINAZOLINES UTILISÉES COMME MODULATEURS DE COT ET LEURS MÉTHODES D'UTILISATION
Abstract: front page image
(EN)The invention relates to 4,6-diaminoquinazoline derivatives of formula I which are modulators of the Cot (cancer Osaka thyroid) kinase, also known as MAP3K8, EST or Tlp-2, and their use for treating e.g. cancer, diabetes and inflammatory diseases.
(FR)L'invention concerne des dérivés de 4,6-diaminoquinazoline de formule I qui sont des modulateurs de la kinase Cot (cancer Osaka thyroid), également appelée MAP3K8, EST ou Tlp -2, et leur utilisation pour le traitement, par exemple, du cancer, du diabète et des maladies inflammatoires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)