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1. (WO2018005177) BICYCLIC IMIDAZOLE DERIVATIES USEFUL FOR THE TREATMENT OF RENAL DISEASE, CARDIOVASCULAR DISEASES AND FIBROTIC DISORDERS

Pub. No.:    WO/2018/005177    International Application No.:    PCT/US2017/038440
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Thu Jun 22 01:59:59 CEST 2017
IPC: C07D 235/02
C07D 401/04
C07D 403/04
C07D 405/04
C07D 471/04
A61K 31/4184
A61P 9/00
A61P 13/12
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventors: MCKIBBEN, Bryan P.
MEYERS, Kenneth Michael
ZHANG, Yunlong
MARSHALL, Daniel Richard
COGAN, Derek
LORD, John
CHEN, Zhidong
BURKE, Jennifer
BALESTRA, Michael
Title: BICYCLIC IMIDAZOLE DERIVATIES USEFUL FOR THE TREATMENT OF RENAL DISEASE, CARDIOVASCULAR DISEASES AND FIBROTIC DISORDERS
Abstract:
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.