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1. (WO2018004906) MODIFIED ALGINATE HYDROGELS FOR THERAPEUTIC AGENTS, THEIR PREPARATION AND METHODS THEREOF
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Pub. No.: WO/2018/004906 International Application No.: PCT/US2017/034748
Publication Date: 04.01.2018 International Filing Date: 26.05.2017
IPC:
A61K 31/18 (2006.01) ,A61K 31/63 (2006.01) ,A61K 31/133 (2006.01) ,A61K 31/135 (2006.01) ,A61K 31/137 (2006.01) ,A61K 31/145 (2006.01) ,A61K 31/195 (2006.01) ,A61K 31/606 (2006.01) ,A61K 31/734 (2006.01) ,A61K 47/36 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
18
Sulfonamides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
63
Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
133
having hydroxy groups, e.g. sphingosine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
137
Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
145
having sulfur atoms, e.g. thiurams (N-C(S)-S-C(S)-N or N-C(S)-S-S-C(S)-N); Sulfinylamines (-NSO); Sulfonylamines (-NSO2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
60
Salicylic acid; Derivatives thereof
606
having amino groups
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
734
Alginic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
Applicants:
WAKE FOREST UNIVERSITY [US/US]; 391 Technology Way, Suite 199 Winston-Salem, NC 27101, US
WAKE FOREST UNIVERSITY HEALTH SCIENCES; Medical Center Boulevard Winston-Salem, North Carolina 27157, US
Inventors:
WELKER, Mark, E.; US
OPARA, Emmanuel, C.; US
BANKS, Surya, R.; US
WEISSENFLUH, Amber N.; US
Agent:
MURPHY, Sherry, L.; US
Priority Data:
62/357,74101.07.2016US
Title (EN) MODIFIED ALGINATE HYDROGELS FOR THERAPEUTIC AGENTS, THEIR PREPARATION AND METHODS THEREOF
(FR) HYDROGELS D’ALGINATE MODIFIÉS POUR AGENTS THÉRAPEUTIQUES, LEUR PRÉPARATION ET PROCÉDÉS ASSOCIÉS
Abstract:
(EN) A novel chemically modified alginate hydfogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an alginate. The chemical structure of alginate is modified using different amities and different methods, including: (1) covalently bonding aminoethyl benzoic acid to the alginate backbone, and (2) oxidizing the vicinal diol in the alginate chain to an aldehyde before coupling to aminoethyl benzoic acid. Alternatively, the combined aromatic compound and carbohydrate can be a dopamine combined with the alginate. The chemically modified alginate and the methods used can be utilized to encapsulate a variety of bioactive substances for oral delivery in humans and animals, including, hot not limited to: (i) drugs, medicines, enzymes, proteins, hormones, and vaccines, (ii) vitamins, minerals, micronutrients and/or other dietary supplements, (iii) probiotics and/or other microorganisms, (iv) cells, cell parts, and/or other biological materials, and/or (v) other bioactive substances.
(FR) Selon la présente invention, un nouvel hydrogel d’alginate chimiquement modifié a été développé, lequel combine un composé aromatique avec un glucide, le composé aromatique étant une ou plusieurs amines combinées avec un alginate. La structure chimique de l’alginate est modifiée au moyen de différents fragments et différents procédés, comprenant : (1) la liaison covalente d’acide aminoéthylbenzoïque au squelette d’alginate, et (2) l’oxydation du diol vicinal dans la chaîne d’alginate en aldéhyde avant le couplage avec l’acide aminoéthylbenzoïque. En variante, le composé aromatique combiné et le glucide peuvent être une dopamine combinée avec l’alginate. L’alginate chimiquement modifié et les procédés utilisés peuvent être utilisés pour encapsuler une variété de substances bioactives pour administration orale chez des humains et des animaux, comprenant, mais non limitées à : (i) des médicaments, des produits médicinaux, des enzymes, des protéines, des hormones et des vaccins, (ii) des vitamines, des minéraux, des micronutriments et/ou d’autres compléments alimentaires, (iii) des probiotiques et/ou d’autres micro-organismes, (iv) des cellules, des parties de cellules et/ou d’autres matériaux biologiques et/ou (v) d’autres substances bioactives.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)