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1. (WO2018004284) PHARMACEUTICAL COMPOSITIONS AND METHODS FOR POTENTIATING GENE SILENCING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/004284 International Application No.: PCT/KR2017/006923
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
C07D 211/82 (2006.01) ,A61K 31/4422 (2006.01) ,A61K 31/4418 (2006.01)
Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY[KR/KR]; Sungkyunkwan Univ.,2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419, KR
Inventors: LEE, Dongki; KR
SON, Da Seul; KR
KIM, Yang Hee; KR
Agent: LEE, Cheo Young; KR
CHANG, Je Hwan; 11F. 123, Teheran-ro Gangnam-gu Seoul 06133, KR
Priority Data:
10-2016-008191429.06.2016KR
Title (EN) PHARMACEUTICAL COMPOSITIONS AND METHODS FOR POTENTIATING GENE SILENCING
(FR) COMPOSITIONS PHARMACEUTIQUES ET PROCÉDÉS DE POTENTIALISATION DU SILENÇAGE GÉNIQUE
Abstract: front page image
(EN) In various aspects and embodiments, the invention provides compounds or agents that potentiate siRNA cellular entry or activity, and provides methods for identifying such compounds or agents. Exemplary agents that act as L-type calcium channel blockers are described herein, and are shown to potentiate gene silencing with cp-asiRNAs.
(FR) Dans divers aspects et modes de réalisation, la présente invention concerne des composés ou des agents qui potentialisent l'entrée ou l'activité cellulaire de l'ARNsi, ainsi que des procédés d'identification de tels composés ou agents. La présente invention décrit des exemples d'agents qui agissent comme bloqueurs des canaux calciques de type L, et démontre qu'ils potentialisent le silençage génique avec des ARNsi cp-a.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)