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1. (WO2018004260) STABLE LIQUID PHARMACEUTICAL PREPARATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/004260    International Application No.:    PCT/KR2017/006855
Publication Date: 04.01.2018 International Filing Date: 28.06.2017
IPC:
A61K 9/08 (2006.01), A61K 47/26 (2006.01), A61K 47/10 (2006.01), A61K 47/14 (2006.01), A61K 9/00 (2006.01), A61K 39/395 (2006.01), A61K 39/00 (2006.01)
Applicants: CELLTRION INC. [KR/KR]; 23, Academy-ro Yeonsu-gu Incheon 22014 (KR)
Inventors: LEE, Joon Won; (KR).
HAN, Won Yong; (KR).
KIM, Su Jung; (KR).
OH, Jun Seok; (KR).
KIM, So Young; (KR).
HONG, Su Hyeon; (KR).
SHIN, Yeon Kyeong; (KR)
Priority Data:
10-2016-0083039 30.06.2016 KR
Title (EN) STABLE LIQUID PHARMACEUTICAL PREPARATION
(FR) PRÉPARATION PHARMACEUTIQUE LIQUIDE STABLE
(KO) 안정한 액체 약제학적 제제
Abstract: front page image
(EN)A stable liquid pharmaceutical preparation according to the present invention contains: an antibody or an antigen-binding fragment thereof; a surfactant; a sugar or a derivative thereof; and a buffer. The stable liquid pharmaceutical preparation according to the present invention has low viscosity while containing a high amount of the antibody, has excellent long-term storage stability on the basis of excellent stability under accelerated conditions and extreme conditions, and can be administered subcutaneously.
(FR)Une préparation pharmaceutique liquide stable selon la présente invention contient : un anticorps ou un fragment de liaison à l'antigène de celui-ci ; un tensioactif ; un sucre ou un dérivé de celui-ci ; et un tampon. La préparation pharmaceutique liquide stable selon la présente invention a une faible viscosité tout en contenant une quantité élevée de l'anticorps, présente une excellente stabilité au stockage à long terme sur la base d'une excellente stabilité dans des conditions accélérées et des conditions extrêmes, et peut être administrée par voie sous-cutanée.
(KO)본 발명에 따른 안정한 액체 약제학적 제제는 항체 또는 이의 항원 결합 단편; 계면활성제; 당 또는 이의 유도체; 및 완충제를 포함한다. 본 발명에 따른 안정한 액체 약제학적 제제는 항체를 고함량으로 포함하면서 낮은 점도를 가지고, 가속 조건 및 가혹 조건에서의 우수한 안정성을 바탕으로 장기간 보관 안정성이 우수하고, 피하 투여가 가능하다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)