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1. (WO2018004052) METHOD FOR OPTIMIZATION OF PLANNING PHASE IN RESPIRATORY GUIDED RADIOTHERAPY USING GEOMETRIC RELATIONSHIP OF PATIENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2018/004052 International Application No.: PCT/KR2016/007874
Publication Date: 04.01.2018 International Filing Date: 20.07.2016
IPC:
A61B 6/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
6
Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
Applicants:
가톨릭대학교 산학협력단 THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 서울시 서초구 반포대로 222, 가톨릭대학교성의교정내 c/o Catholic University of Korea Songeui Campus 222, Banpo-daero, Seocho-gu Seoul 06591, KR
Inventors:
강성희 KANG, Seong-Hee; KR
김시용 KIM, Siyong; US
김태호 KIM, Tae-Ho; KR
김동수 KIM, Dong-Su; KR
신동석 SHIN, Dong-Seok; KR
조민석 CHO, Min-Seok; KR
김경현 KIM, Kyeong-Hyeon; KR
노유윤 NOH, Yu-Yun; KR
서태석 SUH, Tae suk; KR
Agent:
특허법인 아이퍼스 IPUS PATENT & LAW FIRM; 서울시 강남구 논현로85길 58 백림빌딩 6층 6th Floor, Baeklim Bldg. 58, Nonheon-ro 85-gil Gangnam-gu Seoul 06234, KR
Priority Data:
10-2016-008253530.06.2016KR
Title (EN) METHOD FOR OPTIMIZATION OF PLANNING PHASE IN RESPIRATORY GUIDED RADIOTHERAPY USING GEOMETRIC RELATIONSHIP OF PATIENT
(FR) PROCÉDÉ D'OPTIMISATION DE PHASE DE PLANIFICATION DANS UNE RADIOTHÉRAPIE GUIDÉE PAR LA RESPIRATION À L'AIDE D'UNE RELATION GÉOMÉTRIQUE D'UN PATIENT
(KO) 환자의 기하학적 관계를 이용한 호흡 연동 방사선 치료에서의 플래닝 페이즈 최적화 방법
Abstract:
(EN) The present invention relates to a method for obtaining an optimized irradiation time point of radiation by finding out the time point at which radiation is least irradiated to general tissue during the respiration of a patient. Specifically, the present invention relates to a method for obtaining the time point at which radiation is least irradiated to general tissue during the respiratory period of a patient by defining a three-dimensional geometric relationship between peripheral tissue and a target volume using biological characteristics of general tissue, such as esophagus or spine, where tumors are not formed, for radiation and an overlap volume histogram. In a method for irradiating radiation to a tumor of a patient according to an aspect of the present invention, the method comprises: a first step for determining an irradiation timing of the radiation using the radiation sensitivity of at least one first organ within a predetermined distance from the tumor among a plurality of organs and the geometric overlapping degree between the first organ and the tumor; and a second step for irradiating the radiation to the tumor at the irradiation timing, wherein the radiation sensitivity and the geometric overlapping degree may vary according to the respiration of the patient.
(FR) La présente invention concerne un procédé permettant d'obtenir un point temporel de rayonnement optimisé en trouvant le moment auquel le rayonnement est au moins irradié au tissu général pendant la respiration d'un patient. En particulier, la présente invention concerne un procédé permettant d'obtenir le moment auquel le rayonnement est au moins irradié au tissu général pendant la période respiratoire d'un patient en définissant une relation géométrique tridimensionnelle entre le tissu périphérique et un volume cible en utilisant les caractéristiques biologiques du tissu général, tels que l'oesophage ou la colonne vertébrale, où les tumeurs ne sont pas formées, pour un rayonnement et un histogramme de volume de chevauchement. Dans un procédé d'irradiation d'une tumeur d'un patient selon un aspect de la présente invention, le procédé comprend : une première étape consistant à déterminer un moment d'irradiation du rayonnement en utilisant la sensibilité au rayonnement d'au moins un premier organe à une distance prédéterminée de la tumeur parmi une pluralité d'organes et le degré de chevauchement géométrique entre le premier organe et la tumeur ; et une seconde étape consistant à irradier le rayonnement vers la tumeur au moment de l'irradiation, la sensibilité au rayonnement et le degré de chevauchement géométrique pouvant varier en fonction de la respiration du patient.
(KO) 본 발명은 환자의 호흡에서 일반 조직에 방사선이 가장 덜 조사되는 시점을 찾아내 최적화된 방사선 조사시점을 구하는 방법에 관한 것이다. 구체적으로 본 발명은 종양이 발생하지 않은 식도, 척추 등 일반 조직의 방사선에 대한 생물학적 특성과 Overlap Volume Histogram을 이용하여 주변 조직과 표적체적의 3차원 기하학적 관계를 정의함으로써 환자의 호흡 주기 중에서 일반조직에 방사선이 가장 적게 조사되는 시점을 구하는 방법에 관한 것이다. 본 발명의 일 양상인 환자의 종양(tumor)에 방사선을 조사하는 방법에 있어서, 복수의 기관(organ) 중 상기 종양으로부터 미리 설정된 거리 이내에 있는 적어도 하나의 제 1 기관의 방사선 민감도와 상기 제 1 기관과 상기 종양간의 기하학적 겹치는 정도를 이용하여 상기 방사선의 조사 타이밍을 결정하는 제 1 단계; 및 상기 조사 타이밍에 상기 방사선을 상기 종양으로 조사하는 제 2 단계;를 포함하되, 상기 방사선 민감도 및 기하학적 겹치는 정도는 상기 환자의 호흡에 따라 변화될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)