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1. (WO2018003983) HANP-FC-CONTAINING MOLECULAR CONJUGATE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/003983 International Application No.: PCT/JP2017/024206
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
C07K 14/58 (2006.01) ,A61K 38/22 (2006.01) ,A61K 39/395 (2006.01) ,A61K 47/60 (2017.01) ,A61K 47/68 (2017.01) ,A61P 9/04 (2006.01) ,A61P 9/12 (2006.01) ,A61P 13/12 (2006.01) ,C07K 16/00 (2006.01) ,C07K 19/00 (2006.01) ,C12N 15/09 (2006.01) ,C12P 1/00 (2006.01) ,C12P 19/18 (2006.01) ,C07K 16/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
58
Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide (ANP); Cardionatrin; Cardiodilatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
[IPC code unknown for A61K 47/60][IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
04
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
1
Preparation of compounds or compositions, not provided for in groups C12P3/-C12P39/121; General processes for the preparation of compounds or compositions by using micro-organisms or enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
18
produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12
against material from bacteria
Applicants: DAIICHI SANKYO COMPANY,LIMITED[JP/JP]; 3-5-1,Nihonbashi Honcho,Chuo-ku, Tokyo 1038426, JP
Inventors: IWAMOTO, Mitsuhiro; JP
OISHI, Shohei; JP
SEKIGUCHI, Yukiko; JP
CHAYA, Hiroyuki; JP
MIYAUCHI, Ryuki; JP
HONDA, Takeshi; JP
Agent: ISHIBASHI, Koki; JP
TAKEMOTO, Toshiyasu; JP
Priority Data:
2016-13145001.07.2016JP
Title (EN) HANP-FC-CONTAINING MOLECULAR CONJUGATE
(FR) CONJUGUÉ MOLÉCULAIRE CONTENANT DU HANP-FC
(JA) hANP-Fc含有分子コンジュゲート
Abstract:
(EN) The invention provides a drug and a method for producing same, said drug having as an active ingredient a conjugate, in which an hANP peptide is bound to a sugar chain (N297 sugar chain) that binds to Asn 297 of an Fc-containing molecule via a polyethylene glycol linker, or a pharmaceutically acceptable salt of the conjugate.
(FR) L'invention concerne un médicament et son procédé de production, ledit médicament ayant comme ingrédient actif un conjugué, dans lequel un peptide hANP est lié à une chaîne de sucre (chaîne de sucre N297) qui se lie à Asn 297 d'une molécule contenant Fc par l'intermédiaire d'un lieur de polyéthylène glycol, ou un sel pharmaceutiquement acceptable du conjugué.
(JA) 本発明は、hANPペプチドがポリエチレングリコールリンカーを介して、Fc含有分子のAsn297に結合する糖鎖(N297糖鎖)に結合したコンジュゲート体またはその薬学上許容される塩、それを有効成分とする医薬、その製造方法などを提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)