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1. (WO2018003945) METHOD FOR PRODUCING BICYCLIC COMPOUND

Pub. No.:    WO/2018/003945    International Application No.:    PCT/JP2017/024031
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Fri Jun 30 01:59:59 CEST 2017
IPC: C07D 313/06
C07C 69/65
C07C 69/76
C07D 307/935
C07B 61/00
Applicants: ONO PHARMACEUTICAL CO., LTD.
小野薬品工業株式会社
Inventors: MORIGUCHI, Hideki
森口 英紀
TANAKA, Yusuke
田中 裕介
INO, Tatsunori
伊野 達徳
KAMBE, Tohru
神戸 透
NISHIYAMA, Taihei
西山 泰平
TSUJIYAMA, Shinichiro
辻山 真一郎
UEDA, Yohei
上田 洋平
Title: METHOD FOR PRODUCING BICYCLIC COMPOUND
Abstract:
[Problem] Provided are a method for producing 2-propanil 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-butene-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepine-3-yl}butanoate, which can solve various problems described in patent document 1, and a novel intermediate suitable for the production method. [Solution] According to the present invention, 2-propanil 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-butene-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepine-3-yl}butanoate can be stably supplied with a high total reaction yield by using a different starting material, and improving metathesis reaction, asymmetric reduction reaction, etc.