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1. (WO2018002614) COMPOUNDS FOR THE DETECTION OF SENESCENT CELLS

Pub. No.:    WO/2018/002614    International Application No.:    PCT/GB2017/051889
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Thu Jun 29 01:59:59 CEST 2017
IPC: C07D 239/70
C09B 31/043
C09B 31/053
Applicants: THE UNIVERSITY OF MANCHESTER
Inventors: GORGOULIS, Vassilis
TOWNSEND, Paul
MARAKOS, Panayiotis
LOUGIAKIS, Nikolaos
POULI, Nicole
KASTRINAKIS, Nikolaos
Title: COMPOUNDS FOR THE DETECTION OF SENESCENT CELLS
Abstract:
The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R1, R2, R3, R4 and Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB).