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1. (WO2018002614) COMPOUNDS FOR THE DETECTION OF SENESCENT CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/002614    International Application No.:    PCT/GB2017/051889
Publication Date: 04.01.2018 International Filing Date: 28.06.2017
IPC:
C07D 239/70 (2006.01), C09B 31/043 (2006.01), C09B 31/053 (2006.01)
Applicants: THE UNIVERSITY OF MANCHESTER [GB/GB]; Oxford Road Manchester Greater Manchester M13 9PL (GB)
Inventors: GORGOULIS, Vassilis; (GR).
TOWNSEND, Paul; (GB).
MARAKOS, Panayiotis; (GR).
LOUGIAKIS, Nikolaos; (GR).
POULI, Nicole; (GR).
KASTRINAKIS, Nikolaos; (GR)
Agent: HGF LIMITED; 4th Floor Merchant Exchange 17-19 Whitworth Street West Manchester Greater Manchester M1 5WG (GB)
Priority Data:
1611208.8 28.06.2016 GB
Title (EN) COMPOUNDS FOR THE DETECTION OF SENESCENT CELLS
(FR) COMPOSÉS POUR LA DÉTECTION DE CELLULES SÉNESCENTES
Abstract: front page image
(EN)The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R1, R2, R3, R4 and Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB).
(FR)La présente invention concerne de novo synthétisé, composé chimique de la formule (1) ou (2) sa fonction est comme des détecteurs de cellules sénescentes où R1, R2, R3, R4 et Z sont tel que défini dans la description. La présente invention concerne également des procédés de préparation de ces composés, leur utilisation dans la détection de cellules sénescentes, des procédés de détection de sénescence dans des cellules et à des kits comprenant lesdits composés. Les composés ont la capacité de réagir avec la lipofuscine, de manière analogue au colorant Noir Soudan B (SBB) histochimique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)