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1. (WO2018002415) NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/002415    International Application No.:    PCT/FI2017/000012
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
C07D 471/04 (2006.01)
Applicants: FERMION OY [FI/FI]; Koivu-Mankkaan tie 6 A FI-02200 Espoo (FI)
Inventors: KATAJA, Antti; (FI)
Agent: ORION CORPORATION; Intellectual Property Rights P.O.Box 65 FI-02101 Espoo (FI)
Priority Data:
20165557 01.07.2016 FI
20165778 12.10.2016 FI
Title (EN) NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB
(FR) NOUVEAUX PROCÉDÉS DE PRÉPARATION DE VEMURAFENIB
Abstract: front page image
(EN)The present invention relates to novel processes for the manufacture of N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (I), wherein no protection-deprotection sequences or halogenation steps are required and the use of palladium catalysts is minimized. Formula (I)
(FR)La présente invention concerne de nouveaux procédés de fabrication de N- (3-(5-(4-chlorophényle)-1H-pyrrolo [2,3-b] pyridine-3-carbonyle)-2,4-difluorophényl) propane-1-sulfonamide (I), dans lequel aucune séquence de protection-déprotection ou étape d'halogénation n'est nécessaire et l'utilisation de catalyseurs au palladium est réduite au minimum.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)