Search International and National Patent Collections

1. (WO2018002382) POLY(CYCLIC IMINO ETHER)S

Pub. No.:    WO/2018/002382    International Application No.:    PCT/EP2017/066489
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Tue Jul 04 01:59:59 CEST 2017
IPC: C08G 73/02
Applicants: UNIVERSITEIT GENT
Inventors: HOOGENBOOM, Richard
VERBRAEKEN, Bart
Title: POLY(CYCLIC IMINO ETHER)S
Abstract:
The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]m-[Oz]n-Nuc (I) wherein: • Ini represents a residue of an initiator of cationic polymerization, • Nuc represents a residue of a nucleophilic agent, • Ox represents N(R1)CHRaCHRa; each R1 independently represents H or C(O)R11; and R11 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; • Oz represents N(R2)CHRaCHRaCHRa; each R2 independently represents C(O)R21 or H; and R21 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; · each Ra independently represents H, linear or branched C1-3 alkyl; • m ≥ 5; • n ≥ 5; • m+n ≥ 20; • 3:97 ≤ m:n ≤ 97:3. The statistical copolymers of the present invention exhibit useful properties that can be exploited in the medical field, especially in polymer micelles for drug delivery and polyplexes for DNA delivery.