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1. (WO2018002290) AMPLIFYING BETA CELL DIFFERENTIATION WITH SMALL MOLECULES BET (BROMODOMAIN AND EXTRATERMINAL FAMILY OF BROMODOMAIN-CONTAINING PROTEINS) INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/002290    International Application No.:    PCT/EP2017/066243
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
C12N 5/071 (2010.01)
Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR/FR]; 3, rue Michel Ange 75016 PARIS (FR).
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, rue de Tolbiac 75013 PARIS (FR).
UNIVERSITE PARIS DESCARTES [FR/FR]; 12, rue de l'Ecole de Médecine 75006 PARIS (FR).
NOVO NORDISK A/S [DK/DK]; NOVO ALLE 2880 BAGSVAERD (DK)
Inventors: HUIJBREGTS, Lukas; (FR).
SCHARFMANN, Raphael; (FR).
HONORE, Christian; (DK)
Agent: REGIMBEAU; 20, rue de Chazelles 75847 PARIS CEDEX 17 (FR)
Priority Data:
16305835.7 01.07.2016 EP
Title (EN) AMPLIFYING BETA CELL DIFFERENTIATION WITH SMALL MOLECULES BET (BROMODOMAIN AND EXTRATERMINAL FAMILY OF BROMODOMAIN-CONTAINING PROTEINS) INHIBITORS
(FR) AMPLIFICATION DE LA DIFFÉRENCIATION DES CELLULES BÊTA AVEC DES INHIBITEURS BET (FAMILLE DU BROMODOMAINE ET EXTRATERMINAL DE PROTÉINES CONTENANT UN BROMODOMAINE) À PETITES MOLÉCULES
Abstract: front page image
(EN)The present invention provides an in vitromethod for obtaining cells of the pancreatic endocrine lineage, comprising a step of culturing pancreatic progenitor cells, wherein said pancreatic progenitor cells are in a cell culture medium comprising at least one BET inhibitor.
(FR)La présente invention concerne un procédé in vitro pour l'obtention de cellules de la lignée endocrine pancréatique, comprenant une étape de culture de cellules progénitrices pancréatiques, lesdites cellules progénitrices pancréatiques étant dans un milieu de culture cellulaire comprenant au moins un inhibiteur de BET.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)