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1. (WO2018002219) CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/002219    International Application No.:    PCT/EP2017/066125
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
C07D 403/12 (2006.01), C07D 405/14 (2006.01), C07D 405/04 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 491/04 (2006.01), C07D 498/04 (2006.01), A61K 31/506 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), A61K 31/5365 (2006.01), A61K 31/5375 (2006.01)
Applicants: JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 2340 Beerse (BE)
Inventors: STANSFIELD, Ian; (FR).
QUEROLLE, Olivier, Alexis, Georges; (FR).
LIGNY, Yannick, Aimé, Eddy; (FR).
GROSS, Gerhard, Max; (BE).
JACOBY, Edgar; (BE).
MEERPOEL, Lieven; (BE).
GREEN, Simon, Richard; (GB).
HYND, George; (GB).
KULAGOWSKI, Janusz, Jozef; (GB).
MACLEOD, Calum; (GB).
MANN, Samuel, Edward; (GB)
Agent: CAMPABADAL I MONFA, Gemma; (BE)
Priority Data:
16177131.6 30.06.2016 EP
16177142.3 30.06.2016 EP
16177147.2 30.06.2016 EP
Title (EN) CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS
(FR) NOUVEAUX DÉRIVÉS DE CYANOINDOLINE COMME INHIBITEURS DE NIK
Abstract: front page image
(EN)Fused aromatic bicyclic substituted 5-(2-amino-4-pyrimidinyl)- cyanoindoline derivatives (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
(FR)Dérivés de 5-(2-amino-4-pyrimidinyl)- cyanoindoline substitué fusionné aromatique bicyclique (I) utilisés pour des thérapies et/ou prophylactique chez un mammifère, et en particulier à des inhibiteurs de NF-KB induisant la kinase (NIK - également connue sous le nom de MAP3K14) utiles pour traiter les maladies telles que le cancer, les troubles inflammatoires, les troubles métaboliques et auto-immunes. La présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, et l'utilisation de ces composés ou compositions pharmaceutiques pour la prévention ou le traitement des maladies telles que le cancer, les troubles inflammatoires, les troubles métaboliques, y compris l'obésité et le diabète, ainsi que les troubles auto-immunes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)