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1. (WO2018002091) METHOD AND DEVICE FOR CLOSED SYSTEM CULTURE OF CARTILAGE TISSUE

Pub. No.:    WO/2018/002091    International Application No.:    PCT/EP2017/065916
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Wed Jun 28 01:59:59 CEST 2017
IPC: C12M 3/00
C12M 1/34
Applicants: GENERAL ELECTRIC COMPANY
GE HEALTHCARE LIMITED
Inventors: KESKAR, Vandana
GRIFFIN, Weston, Blaine
ZHANG, Xiaohua
Title: METHOD AND DEVICE FOR CLOSED SYSTEM CULTURE OF CARTILAGE TISSUE
Abstract:
The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor maybe equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.