Search International and National Patent Collections
|1. (WO2018001918) TRIAZOLOPYRIDINES AS GAMMA-SECRETASE MODULATORS|
|Applicants:||F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
RODRIGUEZ SARMIENTO, Rosa Maria
|Title:||TRIAZOLOPYRIDINES AS GAMMA-SECRETASE MODULATORS|
The present invention relates to compounds of formula (I) HetAr is a five or six membered hetaryl group, containing one, two or three heteroatoms, selected from N, O or S; R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen or lower alkoxy; R2 is lower alkyl substituted by halogen; R3 is hydrogen, lower alkyl substituted by halogen, lower alkyl or lower alkyl substituted by hydroxy; Y is formula (A) or (B); R4 is lower alkoxy, lower alkoxy substituted by halogen or CN; or to pharmaceutically active acid addition salts thereof, to racemic mixtures or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.