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1. (WO2018001918) TRIAZOLOPYRIDINES AS GAMMA-SECRETASE MODULATORS

Pub. No.:    WO/2018/001918    International Application No.:    PCT/EP2017/065617
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Tue Jun 27 01:59:59 CEST 2017
IPC: C07D 471/04
A61K 31/437
A61P 25/28
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: BARTELS, Bjoern
JAKOB-ROETNE, Roland
LIMBERG, Anja
NEIDHART, Werner
RATNI, Hasane
RODRIGUEZ SARMIENTO, Rosa Maria
Title: TRIAZOLOPYRIDINES AS GAMMA-SECRETASE MODULATORS
Abstract:
The present invention relates to compounds of formula (I) HetAr is a five or six membered hetaryl group, containing one, two or three heteroatoms, selected from N, O or S; R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen or lower alkoxy; R2 is lower alkyl substituted by halogen; R3 is hydrogen, lower alkyl substituted by halogen, lower alkyl or lower alkyl substituted by hydroxy; Y is formula (A) or (B); R4 is lower alkoxy, lower alkoxy substituted by halogen or CN; or to pharmaceutically active acid addition salts thereof, to racemic mixtures or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.