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1. (WO2018001393) SUBSTITUTED THIENOPYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE

Pub. No.:    WO/2018/001393    International Application No.:    PCT/CZ2016/050021
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Thu Jun 30 01:59:59 CEST 2016
IPC: C07H 19/24
A61K 31/7042
A61P 35/00
Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.
UNIVERZITA PALACKEHO V OLOMOUCI
Inventors: HOCEK, Michal
TICHY, Michal
HAJDUCH, Marian
DZUBAK, Petr
Title: SUBSTITUTED THIENOPYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE
Abstract:
Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use The invention provides a new group of substituted thienopyrrolopyrimidine ribonucleosides of general formula I, wherein R is defined in the claims. The compounds of this invention show strong cytostatic and cytotoxic activities preferably against cancer cell lines of broad spectrum of diseases including tumors of various histogenetic origin.