WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018001331) IMIDAZOPYRIDINAMINE PHENYL DERIVATIVE AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/001331 International Application No.: PCT/CN2017/090908
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
C07D 487/04 (2006.01) ,A61K 31/4985 (2006.01) ,A61P 19/02 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01) ,A61P 11/06 (2006.01) ,A61P 37/08 (2006.01) ,A61P 3/10 (2006.01) ,A61P 19/04 (2006.01)
Applicants: YIN, Jianming[US/US]; US
HANGZHOU HUADONG MEDICINE GROUP PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD.[CN/CN]; No.866 Monganshan Road, Gongshu District Hangzhou, Zhejiang 310011, CN
Inventors: YIN, Jianming; US
LV, Yubin; CN
LI, Bangliang; CN
Agent: SUZHOU CREATOR PATENT & TRADEMARK AGENCY LTD.; No.93 Ganjiang West Road Suzhou, Jiangsu 215002, CN
Priority Data:
201610533291.X30.06.2016CN
201611062661.225.11.2016CN
Title (EN) IMIDAZOPYRIDINAMINE PHENYL DERIVATIVE AND USE THEREOF
(FR) DÉRIVÉ D'IMIDAZOPYRIDINAMINE PHÉNYLE ET SON UTILISATION
(ZH) 一种咪唑吡啶胺苯基衍生物及其用途
Abstract:
(EN) The present invention relates to an imidazopyridinamine phenyl derivative, pharmaceutically acceptable salt thereof, hydrate or metabolite formed by metabolizing in any form, and use thereof in the preparation of a medicament for preventing and/or treating indications associated with BTK function. The imidazopyridinamine phenyl derivative according to the present invention is an ideal high-efficiency BTK inhibitor for treating or preventing diseases such as rheumatoid arthritis, B-cell lymphoma, leukemia, multiple myeloma, allergies, asthma, multiple sclerosis, type I diabetes and systemic lupus erythematosus.
(FR) La présente invention concerne un dérivé d'imidazopyridinamine phényle, un sel pharmaceutiquement acceptable de celui-ci, un hydrate ou un métabolite formé par métabolisation sous une forme quelconque, et leur utilisation dans la préparation d'un médicament pour la prévention et/ou le traitement des indications associées à la fonction de BTK. Le dérivé d'imidazopyridinamine phényle selon la présente invention est un inhibiteur idéal de BTK à haut rendement pour le traitement ou la prévention de maladies telles que la polyarthrite rhumatoïde, le lymphome à cellules B, la leucémie, le myélome multiple, les allergies, l'asthme, la sclérose en plaques, le diabète de type I et le lupus érythémateux systémique.
(ZH) 本发明涉及一种咪唑吡啶胺苯基衍生物,其可药用盐、水合物或以任何形式代谢形成的代谢产物,及在制备预防和/或治疗与BTK功能有关的适应症的药物中的用途。本发明的咪唑吡啶胺苯基衍生物是理想的高效BTK抑制剂,可用于治疗或预防类风湿性关节炎、B细胞淋巴瘤、白血病、多发性骨髓瘤、过敏、哮喘、多发性硬化、I型糖尿病和全身性红斑狼疮等疾病。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)