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1. (WO2018001287) APPLICATION OF METHYL 4-[9-(6-AMINOPURYL)]-2(S)-HYDROXYBUTYRATE IN PREPARATION OF MEDICAMENT FOR TREATING PSORIASIS AND VITILIGO
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2018/001287 International Application No.: PCT/CN2017/090684
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
A61K 31/52 (2006.01) ,A61P 17/06 (2006.01) ,A61P 17/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
Applicants:
中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国上海市 浦东张江祖冲之路555号 555 Zu Chong Zhi Road Zhang Jiang, Pudong Shanghai 201203, CN
宁波紫园药业有限责任公司 NINGBO ZIYUAN PHARMACEUTICALS INC. [CN/CN]; 中国浙江省宁波市 宁海县跃龙街道兴海中路439号 No.439 Xinghai Zhong Lu Yuelong Street, Ninghai County Ningbo, Zhejiang 315600, CN
Inventors:
左建平 ZUO, Jianping; CN
唐炜 TANG, Wei; CN
林泽民 LIN, Zemin; CN
袁崇生 YUAN, Chongsheng; US
Agent:
北京金信知识产权代理有限公司 KINGSOUND & PARTNERS; 中国北京市 海淀区紫竹院路116号嘉豪国际中心B座11层 11/F, Block B, King Sound International Center 116 Zizhuyuan Road, Haidian District Beijing 100097, CN
Priority Data:
201610510528.230.06.2016CN
Title (EN) APPLICATION OF METHYL 4-[9-(6-AMINOPURYL)]-2(S)-HYDROXYBUTYRATE IN PREPARATION OF MEDICAMENT FOR TREATING PSORIASIS AND VITILIGO
(FR) APPLICATION DE MÉTHYL 4-[9- (6-AMINOPURYL)]-2 (S)-HYDROXYBUTYRATE DANS LA PRÉPARATION D'UN MÉDICAMENT POUR LE TRAITEMENT DU PSORIASIS ET DU VITILIGO.
(ZH) 4-[9-(6-氨基嘌呤基)]-2(S)-羟基丁酸甲酯在制备治疗银屑病及白癜风药物中的应用
Abstract:
(EN) Provided in the present invention is a use of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate in the preparation of a medicament for treating psoriasis and vitiligo. More specifically, the present invention uses mice whose psoriasis is induced by an imiquimod cream to observe a changing condition in skin lesions on the psoriasis-like mice, according to a psoriasis skin lesion area of the mice and grading standards for disease severity; the present invention also observes a proportion of lymphocytes in the spleens and cytokines in skin lesion tissues of the mice. A good therapeutic effect may be obtained by treating typical cases of vitiligo with an ointment of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate. Results show that methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate used in the present invention has a good therapeutic effect on psoriasis and vitiligo, as well as a favorable prospect in clinical application.
(FR) L'invention porte sur l'utilisation de méthyl 4-[9- (6-aminopuryl)]-2(s)-hydroxybutyrate dans la préparation d'un médicament pour le psoriasis et le vitiligo. Des souris, dont le psoriasis est provoqué par une crème d'imiquimod, développent des lésions cutanées, catégorisées selon la zone de lésion du psoriasis et les normes de notation pour la gravité de la maladie. L'invention observe également une partie des lymphocytes dans les rate et des cytokines dans les tissus de lésions cutanées des souris. On peut obtenir un effet thérapeutique en traitant les cas typiques du vitiligo avec un onguent de méthyl 4-[9- (6-aminopuryl)]-2 (s)-hydroxybutyrate.
(ZH) 本发明提供4-[9-(6-氨基嘌呤基)]-2(S)-羟基丁酸甲酯在制备治疗银屑病及白癜风药物中的用途,具体而言,本发明通过对用咪喹莫特乳膏诱导银屑病小鼠的银屑病皮损面积和疾病严重程度评分标准观察银屑病样小鼠皮损的变化情况,及小鼠脾脏中淋巴细胞比例和皮损组织中细胞因子的观察。在白癜风典型病例中采用4-[9-(6-氨基嘌呤基)]-2(S)-羟基丁酸甲酯软膏治疗,获得了良好的治疗效果。结果显示,本发明采用的4-[9-(6-氨基嘌呤基)]-2(S)-羟基丁酸甲酯对银屑病及白癜风有良好的治疗作用,具有良好的临床应用前景。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
AU2017287461CA3028828EP3479826