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1. (WO2018000450) TETRAHYDROTHIOPYRANOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
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Pub. No.: WO/2018/000450 International Application No.: PCT/CN2016/089710
Publication Date: 04.01.2018 International Filing Date: 12.07.2016
IPC:
C07D 495/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 31/18 (2006.01)
Applicants: SHANDONG UNIVERSITY[CN/CN]; NO.27 Shanda Nan Rd., Licheng District Jinan, Shandong 250100, CN
Inventors: LIU, Xinyong; CN
ZHANG, Heng; CN
ZHAN, Peng; CN
ZHOU, Zhongxia; CN
KANG, Dongwei; CN
Agent: JINAN JINDI INTELLECTUAL PROPERTY AGENCY CO., LTD.; NO.27 Shanda Nan Rd., Licheng District Jinan, Shandong 250100, CN
Priority Data:
201610488310.127.06.2016CN
Title (EN) TETRAHYDROTHIOPYRANOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) DÉRIVÉ DE TÉTRAHYDROTHIOPYRANOPYRIMIDINE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 四氢噻喃并嘧啶类衍生物及其制备方法与应用
Abstract: front page image
(EN) A tetrahydrothiopyranopyrimidine compound, a preparation method therefor and an application thereof. The tetrahydrothiopyranopyrimidine compound or a pharmaceutically acceptable salt or prodrug has the structure as shown in the general formula I or II below. Further included are a method for preparing the tetrahydrothiopyranopyrimidine compound, and an application of a composition comprising one or more of the compounds in the preparation of a medicament for treating or preventing human immunodeficiency virus (HIV).
(FR) Un composé de tétrahydrothiopyranopyrimidine, son procédé de préparation et son application. Le composé de tétrahydrothiopyranopyrimidine ou un sel pharmaceutiquement acceptable ou un promédicament possède la structure telle que représentée dans la formule générale I ou II ci-dessous. L'invention concerne également un procédé de préparation du composé de tétrahydrothiopyranopyrimidine, et une application d'une composition comprenant un ou plusieurs des composés dans la préparation d'un médicament destiné au traitement ou à la prévention du virus de l'immunodéficience humaine (VIH)
(ZH) 一种四氢噻喃并嘧啶类化合物及其制备方法和应用,所述四氢噻喃并嘧啶类化合物或其药学上可接受的盐或前药,具有如下通式(I)或(II)所示的结构。还包括四氢噻喃并嘧啶类化合物的制备方法以及含有一个或多个此类化合物的组合物在制备治疗和预防人免疫缺陷病毒(HIV)药物中的应用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)