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1. (WO2018000047) METHOD OF TREATING IMMUNOGLOBULIN LIGHT CHAIN AMYLOIDOSIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/000047 International Application No.: PCT/AU2017/050678
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
A61K 31/4709 (2006.01) ,A61K 31/47 (2006.01) ,A61P 39/04 (2006.01) ,A61P 43/00 (2006.01) ,A61P 9/00 (2006.01)
Applicants: PRANA BIOTECHNOLOGY LIMITED[AU/AU]; Level 2 369 Royal Parade Parkville, Victoria 3052, AU
Inventors: DIOMEDE, Luisa; IT
SALMONA, Mario; IT
Agent: GRIFFITH HACK; GPO Box 1285 Melbourne, Victoria 3001, AU
Priority Data:
201690259401.07.2016AU
Title (EN) METHOD OF TREATING IMMUNOGLOBULIN LIGHT CHAIN AMYLOIDOSIS
(FR) MÉTHODE DE TRAITEMENT DE L'AMYLOSE À CHAÎNE LÉGÈRE D'IMMUNOGLOBULINE
Abstract:
(EN) The present invention relates to the use of substituted quinoline compounds for treating immunoglobulin light chain (LC) amyloidosis (AL), especially cardiotoxicity associated with immunoglobulin LC AL. In particular, the substituted quinoline compounds useful in the treatment of cardiac LC amyloidosis are 5,7-dihalo-8-hydroxyquinoline derivatives, especially 5,7-dichloro-8-hydroxyquinoline derivatives.
(FR) La présente invention concerne l'utilisation de composés de quinoléine substitués pour le traitement de l'amylose (AL) à chaîne légère d'immunoglobuline (LC), en particulier la cardiotoxicité associée à l'immunoglobuline LCAL. En particulier, les composés de quinoléine substitués utiles dans le traitement de l'amylose LC cardiaque sont des dérivés de 5,7-dihalo-8-hydroxyquinoléine, notamment les dérivés de 5,7-dichloro-8-hydroxyquinoléine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)