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1. WO2017218704 - STABILIZED FORMULATIONS OF LIPID NANOPARTICLES

Publication Number WO/2017/218704
Publication Date 21.12.2017
International Application No. PCT/US2017/037551
International Filing Date 14.06.2017
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
19
lyophilised
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A61K 9/19 (2006.01)
A61K 9/51 (2006.01)
CPC
A61K 47/26
A61K 48/00
A61K 9/19
A61K 9/5123
Applicants
  • MODERNATX, INC. [US/US]; 200 Technology Square Cambridge, Massachusetts 02139, US
Inventors
  • SMITH, Mike; US
  • ALMARSSON, Orn; US
  • BRITO, Luis; US
Agents
  • ERLACHER, Heidi A.; US
  • OUYANG, Lian; US
  • PEMBERTON, Christine C.; US
Priority Data
62/350,11814.06.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STABILIZED FORMULATIONS OF LIPID NANOPARTICLES
(FR) FORMULATIONS STABILISÉES DE NANOPARTICULES LIPIDIQUES
Abstract
(EN)
The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles further including therapeutics and/or prophylactics such as RNA are useful in the delivery of therapeutics and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
(FR)
La présente invention concerne de nouveaux lipides et des compositions les comprenant. Les nanoparticules lipidiques selon l'invention comprennent un nouveau lipide ainsi que des lipides supplémentaires, tels que des phospholipides, des lipides structuraux, et des lipides PEG. Les nanoparticules lipidiques comprenant en outre des agents thérapeutiques et/ou prophylactiques tels que de l'ARN sont utiles dans l'administration d'agents thérapeutiques et/ou prophylactiques à des cellules ou des organes de mammifère pour, par exemple, réguler l'expression de polypeptides, de protéines, ou de gènes.
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