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1. (WO2017216505) NOVEL FUSION PROTEINS AND USE THEREOF FOR PREPARING VACCINES
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Pub. No.: WO/2017/216505 International Application No.: PCT/FR2017/051591
Publication Date: 21.12.2017 International Filing Date: 16.06.2017
IPC:
C07K 14/005 (2006.01) ,C12N 15/62 (2006.01) ,A61K 39/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
Applicants:
UNIVERSITE DE TOURS [FR/FR]; 60, rue Plat d'Etain B.P. 12050 37020 TOURS CEDEX 1, FR
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS [FR/FR]; 2 boulevard Tonnellé 37044 TOURS CEDEX 09, FR
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM [FR/FR]; FR
Inventors:
HOURIOUX, Christophe; FR
PATIENT, Romuald; FR
BEAUMONT, Elodie; FR
ROINGEARD, Philippe; FR
Agent:
GROSSET-FOURNIER, Chantal; FR
BOURGOUIN, André; FR
Priority Data:
16/5567717.06.2016FR
Title (EN) NOVEL FUSION PROTEINS AND USE THEREOF FOR PREPARING VACCINES
(FR) NOUVELLES PROTEINES DE FUSION ET LEUR APPLICATION POUR LA PREPARATION DE VACCINS
Abstract:
(EN) The present invention relates to an immunogenic fusion protein comprising at least the following two peptides a) - on the C-terminal side, a first peptide constituted of: - the amino acid sequence of the protein S or the protein M of a human hepatitis B virus (HBV) isolate, which protein S or protein M is optionally deleted at the N-terminal end thereof, and b) - on the N-terminal side, a second peptide constituted of: - the sequence of amino acids of at least one transmembrane domain and the ectodomain of at least one protein of a Zika virus isolate selected from the envelope protein E or a fusion peptide comprising the envelope protein E and the protein prM.
(FR) La présente invention concerne une protéine de fusion immunogène comprenant au moins les deux peptides suivants : a) - du côté C-terminal, un premier peptide constitué : - de la séquence d'acides aminés de la protéine S ou de la protéine M d'un isolât du virus humain de l'hépatite B (HBV), laquelle protéine S ou protéine M est délétée ou non à son extrémité N-terminale, et b) - du côté N-terminal, un second peptide constitué : - de la séquence d'acides aminés d'au moins un domaine transmembranaire et de l'ectodomaine d'au moins une protéine d'un isolât du virus Zika choisie parmi la protéine d'enveloppe E ou un peptide de fusion comprenant la protéine d'enveloppe E et la protéine prM.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)