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1. WO2017210381 - BIOCONVERSION OF 1-CARBON FEEDSTOCKS TO CHEMICALS AND FUELS

Publication Number WO/2017/210381
Publication Date 07.12.2017
International Application No. PCT/US2017/035364
International Filing Date 01.06.2017
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
16
Yeasts; Culture media therefor
19
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
52
Genes encoding for enzymes or proenzymes
C12N 1/15 (2006.01)
C12N 1/19 (2006.01)
C12N 1/21 (2006.01)
C12N 9/00 (2006.01)
C12N 15/52 (2006.01)
CPC
C12N 15/52
C12N 9/00
C12N 9/0006
C12N 9/1029
C12P 7/00
C12P 7/04
Applicants
  • WILLIAM MARSH RICE UNIVERSITY [US/US]; 6100 Main Street Houston, TX 77005, US
Inventors
  • GONZALEZ, Ramon; US
  • CHOU, Alexander; US
Agents
  • VALOIR, Tamsen; US
  • BOULWARE, Margaret; US
  • HSIEH, Meng-tien; US
  • ELLISON, Sparkle; US
Priority Data
62/344,82502.06.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOCONVERSION OF 1-CARBON FEEDSTOCKS TO CHEMICALS AND FUELS
(FR) BIOCONVERSION DE MATIÈRES PREMIÈRES DE 1-CARBONE EN PRODUITS CHIMIQUES ET EN COMBUSTIBLES
Abstract
(EN)
A method for the biosynthesis of carbon-based products of interest by assimilation of single carbon feedstocks is described. A reaction pathway that consolidates carbon fixation, central metabolism, and product synthesis is designed and implemented as either a genetically engineered microorganism or as an enzyme reaction mixture. The invention makes use of a carbon-carbon bond formation mechanism that has not been previously exploited for this purpose and which is based on the use of formate acyltransferases. The result is a method that allows for production of chemical products by the utilization of either solely single carbon feedstocks or a mixture of single and multi-carbon feedstocks.
(FR)
La présente invention porte également sur un procédé de biosynthèse de produits à base de carbone d'intérêt par l'assimilation de matières premières de carbone uniques. Une voie de réaction qui consolide la fixation du carbone, le métabolisme central et la synthèse du produit est conçue et mise en œuvre sous la forme d'un micro-organisme génétiquement modifié ou d'un mélange de réaction enzymatique. La présente invention utilise un mécanisme de formation de liaisons carbone-carbone qui n'a pas été précédemment exploité à cet effet et qui est basé sur l'utilisation de formiate acyltransférases. Le résultat est un procédé qui permet la production de produits chimiques par l'utilisation soit uniquement de matières premières de carbone uniques, soit d'un mélange de matières premières mono- et multi-carbonées.
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