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1. (WO2017205857) SYSTEMS AND METHODS FOR 4-D HYPERSPECTRIAL IMAGING

Pub. No.:    WO/2017/205857    International Application No.:    PCT/US2017/034875
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Sun May 28 01:59:59 CEST 2017
IPC: G01N 21/64
G02B 21/00
G02B 21/16
G01J 3/44
G01J 3/18
G01J 3/28
Applicants: VERILY LIFE SCIENCES LLC
Inventors: SANTORI, Charles
SINHA, Supriyo
WU, Cheng-Hsun
HIGBIE, James
LEE, Seung, Ah
Title: SYSTEMS AND METHODS FOR 4-D HYPERSPECTRIAL IMAGING
Abstract:
Systems and methods for hyperspectral imaging are described. A hyperspectral imaging system (300), comprising: a sample holder (370) configured to hold a sample; a light source (3010) configured to emit excitation light (402) having one or more wavelengths; a two-dimensional imaging device (380); and an optical system comprising: a first spatial light modulator (320a); a first dispersive element (340a); and a second dispersive element (340b); wherein the optical system is configured to (i) structure the excitation light (402), using the first spatial light modulator (320a), into a predetermined two-dimensional excitation pattern at a conjugate plane of a focal plane in the sample; (ii) spectrally disperse, using the first dispersive element (340a), the excitation light (404); (iii) use excitation pattern (406) to illuminate the sample illuminate the sample in an excitation pattern (406) with the one or more wavelengths dispersed along a first lateral direction within the focal plane; (iv) collect, from the sample, emission light (408); (v) spectrally disperse, using the second dispersive element (340b), the collected emission light (408); and (vi) provide the collected emission light (410) in-focus to the imaging device (380) such that the spectrally dispersed emission light (410) is spectrally dispersed along a second lateral direction.