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1. (WO2017205852) PROTEIN INTERFACES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/205852    International Application No.:    PCT/US2017/034870
Publication Date: 30.11.2017 International Filing Date: 26.05.2017
IPC:
A61K 38/00 (2006.01), C07K 14/435 (2006.01)
Applicants: SYNTHEX, INC. [US/US]; 953 Indiana Street San Francisco, CA 94103 (US)
Inventors: CHAHWAN, Charly; (US).
SOLOVEYCHIK, Maria; (US)
Agent: SKUBATCH, Maya; (US).
ALMEDA, Dariela; (US).
ADVANI, Raj; (US).
AGRAWAL, Trisha; (US).
ALEMOZAFAR, Ali; (US)
Priority Data:
62/384,226 07.09.2016 US
62/342,840 27.05.2016 US
Title (EN) PROTEIN INTERFACES
(FR) INTERFACES DE PROTÉINES
Abstract: front page image
(EN)The present disclosure provides methods to treat conditions, including cancer, using compounds that can target resistant cancer cells. The compounds can be used to sensitize resistant cancer cells or decrease the proliferation of cells. The compounds can target proteins in the DNA damage repair pathway leading to a decrease in DNA damage repair in target cells.
(FR)La présente invention concerne des méthodes pour traiter des maladies, notamment le cancer, à l'aide de composés qui peuvent cibler des cellules cancéreuses résistantes. Les composés peuvent être utilisés pour sensibiliser des cellules cancéreuses résistantes ou pour diminuer la prolifération de cellules. Les composés peuvent cibler des protéines dans la voie de réparation des lésions de l'ADN conduisant à une diminution de la réparation des lésions de l'ADN dans les cellules cibles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)