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1. (WO2017205798) SYSTEM AND METHOD FOR LASER DESORPTION LONIZATION-MASS SPECTROMETRY ANALYSIS OF BIOMOLECULES IN CELLULAR COMPARTMENTS

Pub. No.:    WO/2017/205798    International Application No.:    PCT/US2017/034778
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Sat May 27 01:59:59 CEST 2017
IPC: B01D 59/44
C12M 1/34
C12Q 1/68
G01N 33/53
G01N 33/552
Applicants: THE GEORGE WASHINGTON UNIVERSITY
Inventors: VERTES, Akos
KORTE, Andrew
DAVIS, Brian
DINN, Sean
Title: SYSTEM AND METHOD FOR LASER DESORPTION LONIZATION-MASS SPECTROMETRY ANALYSIS OF BIOMOLECULES IN CELLULAR COMPARTMENTS
Abstract:
A system and method of performing mass spectrometry analysis on a sample such as a cellular component subject to laser desorption ionization is disclosed. A cell sample is lysed. An antibody is attached to a columnar array. The lysed cell sample for analysis is placed on the columnar array. The antibody retains components of the cell sample on the array to selectively capture cellular components of the cell sample. A laser is used to desorb and ionize the components of the cell sample. Mass spectrometry is performed on the ionized cell components.