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1. (WO2017205766) INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/205766    International Application No.:    PCT/US2017/034721
Publication Date: 30.11.2017 International Filing Date: 26.05.2017
IPC:
C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 495/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: PHARMACYCLICS LLC [US/US]; 995 East Arques Avenue Sunnyvale, CA 94085 (US)
Inventors: CHEN, Wei; (US).
JIA, Zhaozhong, J.; (US).
THOMAS, William, D.; (US).
WONE, David; (US).
MORIN, Matthew, D.; (US)
Agent: RUSSELL, Hathaway, P.; (US).
CHOI, Philip, S.; (US).
BLOUNT, Jennifer, V.; (US).
BENNETT, Jonathan, D.; (US).
AKHIEZER, Alexander; (US)
Priority Data:
62/342,465 27.05.2016 US
Title (EN) INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE
(FR) INHIBITEURS DE LA KINASE ASSOCIÉE AU RÉCEPTEUR DE L'INTERLEUKINE-1
Abstract: front page image
(EN)Disclosed herein are inhibitors of IRAK protein kinase of formula (I). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the IRAK inhibitors are described, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
(FR)Cette invention concerne des inhibiteurs de la protéine kinase IRAK de formule (I). L'invention concerne également des compositions pharmaceutiques qui comprennent ces composés. L'invention concerne enfin des procédés d'utilisation des inhibiteurs d'IRAK, seuls ou en combinaison avec d'autres agents thérapeutiques, pour le traitement de maladies ou d'affections auto-immunes, de maladies ou d'affections hétéro-immunes, du cancer, y compris le lymphome, et de maladies ou d'affections inflammatoires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)