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1. (WO2017205756) 6-THIO-2'-DEOXYGUANOSINE (6-THIO-DG) RESULTS IN TELOMERASE DEPENDENT TELOMERE DYSFUNCTION AND CELL DEATH IN THERAPY-RESISTANT CANCER CELLS

Pub. No.:    WO/2017/205756    International Application No.:    PCT/US2017/034706
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Sat May 27 01:59:59 CEST 2017
IPC: A61K 31/522
A61K 31/7076
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
Inventors: SHAY, Jerry, W.
ZHANG, Gao
Title: 6-THIO-2'-DEOXYGUANOSINE (6-THIO-DG) RESULTS IN TELOMERASE DEPENDENT TELOMERE DYSFUNCTION AND CELL DEATH IN THERAPY-RESISTANT CANCER CELLS
Abstract:
The present disclosure provide for methods of using 6-thio-2'-deoxyguanosine (6-thio- dG) to treat telomerase-positive cancers that exhibit (a) one or more TERT promoter mutations, and/or (b) enriched telomere transcriptional signature(s). In particular, melanomas, including those who are not sensitive or have become resistant to immune checkpoint inhibition and/or MAPKi therapy are targets for this therapy.