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1. (WO2017205747) FLT3-SPECIFIC CHIMERIC ANTIGEN RECEPTORS AND METHODS USING SAME
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Pub. No.: WO/2017/205747 International Application No.: PCT/US2017/034691
Publication Date: 30.11.2017 International Filing Date: 26.05.2017
IPC:
C07K 16/28 (2006.01) ,A61K 38/00 (2006.01) ,A61K 39/395 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660, US
Inventors:
CHIEN, Christopher D.; US
FRY, Terry J.; US
Agent:
SPENNER, Jonathan M.; US
LEYDIG, VOIT & MAYER, LTD.; Two Prudential Plaza, Suite 4900 180 North Stetson Avenue Chicago, Illinois 60601-6731, US
Priority Data:
62/342,39427.05.2016US
Title (EN) FLT3-SPECIFIC CHIMERIC ANTIGEN RECEPTORS AND METHODS USING SAME
(FR) RÉCEPTEURS D'ANTIGÈNES CHIMÉRIQUES SPÉCIFIQUES DE FLT3 ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) An embodiment of the invention provides a chimeric antigen receptor (C AR) comprising an antigen binding domain specific for FLT3, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed.
(FR) Un mode de réalisation de la présente invention concerne un récepteur antigénique chimérique (CAR) comprenant un domaine de liaison à un antigène spécifique de FLT3, un domaine transmembranaire et un domaine de signalisation des lymphocytes T intracellulaire. L'invention concerne également des acides nucléiques, des vecteurs d'expression de recombinaison, des cellules hôtes, des populations de cellules, des anticorps ou leurs parties de liaison à un antigène et des compositions pharmaceutiques concernant les CAR. La présente invention concerne en outre des procédés de détection de la présence d'une pathologie proliférative, par ex. du cancer, chez un mammifère et des procédés de traitement ou de prévention d'une pathologie proliférative, par ex. du cancer, chez un mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)