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1. (WO2017205746) METHODS OF DIFFERENTIATING STEM CELL-DERIVED PROPRIOCEPTORS

Pub. No.:    WO/2017/205746    International Application No.:    PCT/US2017/034690
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Sat May 27 01:59:59 CEST 2017
IPC: C12N 5/079
C12N 5/0793
C12N 5/0797
Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER
Inventors: STUDER, Lorenz
ZELTNER, Nadja
Title: METHODS OF DIFFERENTIATING STEM CELL-DERIVED PROPRIOCEPTORS
Abstract:
The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells (e.g., human stem cells) into proprioceptors, proprioceptors generated by such methods, and compositions comprising such proprioceptors. The presently disclosed subject matter also provides for uses of such proprioceptors for preventing and/or treating disorders of proprioceptor neurons and/or neurodegenerative disorders (e.g., Friedreich's Ataxia).