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1. (WO2017205709) TRIAZOLONES AND TETRAZOLONES AS INHIBITORS OF ROCK

Pub. No.:    WO/2017/205709    International Application No.:    PCT/US2017/034613
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Sat May 27 01:59:59 CEST 2017
IPC: C07D 401/10
C07D 403/10
C07D 403/14
C07D 471/04
C07D 487/04
A61K 31/519
A61P 9/00
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: MURUGESAN, Natesan
GLUNZ, Peter W.
BODAS, Mandar Shrikrishna
YADAV, Navnath Dnyanoba
ALLA, Venu
Title: TRIAZOLONES AND TETRAZOLONES AS INHIBITORS OF ROCK
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.