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1. (WO2017205559) ENGINEERED ANUCLEATE CELLULAR AND EXTRACELLULAR VESICLES AS A NOVEL BIOLOGICS DELIVERY PLATFORM
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/205559    International Application No.:    PCT/US2017/034360
Publication Date: 30.11.2017 International Filing Date: 25.05.2017
IPC:
C12N 5/074 (2010.01), C12N 5/078 (2010.01), C12N 5/0789 (2010.01), A61K 35/12 (2015.01), A61K 35/18 (2015.01), A61K 35/545 (2015.01), A61P 9/10 (2006.01), A61P 35/00 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 N. Charles Street Baltimore, Maryland 21218 (US)
Inventors: CHENG, Linzhao; (US).
BAI, Hao; (US).
MACHAIRAKI, Vasiliki; (US)
Agent: FEULNER, Gregory; (US)
Priority Data:
62/341,243 25.05.2016 US
Title (EN) ENGINEERED ANUCLEATE CELLULAR AND EXTRACELLULAR VESICLES AS A NOVEL BIOLOGICS DELIVERY PLATFORM
(FR) VÉSICULES CELLULAIRES ET EXTRACELLULAIRES ANUCLÉÉES GÉNÉTIQUEMENT MODIFIÉES À TITRE DE NOUVELLE PLATEFORME D'ADMINISTRATION DE SUBSTANCES BIOLOGIQUES
Abstract: front page image
(EN)The present invention is based on the discovery of genetic engineered induced pluripotent stem cells (iPSCs) that produce one or more therapeutic entities such as antibodies and nucleic acids that when administered to a subject, will treat or prevent disease. The present invention also combines EMV technology with iPSC technology creating a powerful new drug delivery platform.
(FR)La présente invention repose sur la découverte de cellules souches pluripotentes induites (iPSC) génétiquement modifiées qui produisent une ou plusieurs entités thérapeutiques telles que des anticorps et des acides nucléiques qui, quand ils sont administrés à un sujet, vont traiter ou prévenir une maladie. La présente invention combine également la technologie EMV à la technologie iPSC pour créer une nouvelle et puissante plateforme d'administration de médicament.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)