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1. (WO2017205541) GROWTH-FACTOR NANOCAPSULES WITH TUNABLE RELEASE CAPABILITY FOR BONE REGENERATION
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Pub. No.: WO/2017/205541 International Application No.: PCT/US2017/034330
Publication Date: 30.11.2017 International Filing Date: 24.05.2017
IPC:
A61K 38/18 (2006.01) ,A61K 9/00 (2006.01) ,A61L 27/58 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
58
Materials at least partially resorbable by the body
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street Twelfth Floor Oakland, California 94607-5200, US
Inventors:
LU, Yunfeng; US
WANG, Jeffrey C.; US
TIAN, Haijun; CN
DU, Juanjuan; US
WEN, Jing; US
LIU, Yang; US
YUAN, Xubo; CN
Agent:
WOOD, William J.; US
Priority Data:
62/340,88224.05.2016US
Title (EN) GROWTH-FACTOR NANOCAPSULES WITH TUNABLE RELEASE CAPABILITY FOR BONE REGENERATION
(FR) NANOCAPSULES DE FACTEUR DE CROISSANCE À CAPACITÉ DE LIBÉRATION RÉGLABLE POUR LA RÉGÉNÉRATION OSSEUSE
Abstract:
(EN) Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.
(FR) Les facteurs de croissance présentent un grand potentiel en médecine régénérative. Cependant, leurs applications cliniques sont en grande partie limitées par de courtes demi-vies in vivo et une fenêtre thérapeutique étroite. Par conséquent, un système fiable de libération contrôlée reste un besoin médical à combler pour les thérapies à base de facteurs de croissance. L'invention concerne un système à libération contrôlée à l'échelle nanométrique (nanocapsule protéique dégradable), obtenu au moyen d'une polymérisation in situ sur le facteur de croissance. La vitesse de libération peut être réglée finement par une mise au point de la composition du polymère de surface. Des résultats thérapeutiques améliorés ont été obtenus avec les nanocapsules de facteur de croissance, comme le montre la fusion de la moelle épinière médiée par des nanocapsules de la protéine morphogénétique osseuse 2 (BMP-2).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)