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1. (WO2017205515) PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/205515    International Application No.:    PCT/US2017/034286
Publication Date: 30.11.2017 International Filing Date: 24.05.2017
IPC:
A61K 31/19 (2006.01), C07C 51/235 (2006.01), C07C 53/134 (2006.01)
Applicants: HORIZON THERAPEUTICS, LLC [US/US]; 150 S. Saunders Rd. Lake Forest, IL 60045 (US).
URAGAMI, Maki [US/US]; (US).
WEISSMAN, Steven [US/US]; (US).
THOMPSON, Andrew [US/US]; (US)
Inventors: URAGAMI, Maki; (US).
WEISSMAN, Steven; (US).
THOMPSON, Andrew; (US).
CHANG, Haui-Chueh; (US).
PFEIFFER, Steven, S.; (US).
ISKOS, Vasilios, H.; (US)
Agent: MARION, Chris; (US)
Priority Data:
15/164,126 25.05.2016 US
Title (EN) PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF
(FR) TECHNIQUE DE PRÉPARATION DE 4-PHÉNYLBUTYRATE ET SES UTILISATIONS
Abstract: front page image
(EN)Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
(FR)L'invention concerne un procédé de préparation de l'acide 4-phényl-1-butyrique, consistant à : faire réagir le 4-phényl-1-butanol avec du chlorite de sodium, un catalyseur à radicaux nitroxyle et de l'hypochlorite de sodium dans un solvant organique et un tampon phosphate ; et à arrêter la réaction avec du sulfite de sodium pour produire de l'acide 4-phényl-1-butyrique. L'invention concerne également l'acide 4-phényl-1-butyrique préparé par un tel procédé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)