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1. (WO2017205511) COMPOSITIONS AND METHODS FOR ORGANOID GENERATION AND DISEASE MODELING

Pub. No.:    WO/2017/205511    International Application No.:    PCT/US2017/034278
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Thu May 25 01:59:59 CEST 2017
IPC: C12N 5/074
C12N 5/095
C12N 5/0789
Applicants: SALK INSTITUTE FOR BIOLOGICAL STUDIES
Inventors: EVANS, Ronald
DOWNES, Michael
ATKINS, Annette
YOSHIHARA, Eiji
YU, Ruth
Title: COMPOSITIONS AND METHODS FOR ORGANOID GENERATION AND DISEASE MODELING
Abstract:
The invention features pancreatic islet and pancreatic organoids, and cell cultures and methods that are useful for the rapid and reliable generation of pancreatic islet and pancreatic islet organoids. The invention also features methods of treating pancreatic diseases and methods of identifying agents that are useful for treatment of pancreatic diseases, such as type 2 diabetes and pancreatic cancer, using the pancreatic islet and pancreatic organoids of the invention.