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1. (WO2017205503) KU INHIBITORS AND THEIR USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/205503    International Application No.:    PCT/US2017/034254
Publication Date: 30.11.2017 International Filing Date: 24.05.2017
IPC:
A61K 31/5377 (2006.01), A61K 31/4523 (2006.01), A61K 31/4439 (2006.01)
Applicants: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US/US]; 518 Indiana Avenue Indianapolis, IN 46202 (US)
Inventors: TURCHI, John, J.; (US).
GAVANDE, Navnath; (US).
VANDERVERE-CAROZZA, Pamela, S.; (US)
Agent: LIPTAK, Vincent, P.; (US)
Priority Data:
62/340,639 24.05.2016 US
Title (EN) KU INHIBITORS AND THEIR USE
(FR) INHIBITEURS DE KU ET LEUR UTILISATION
Abstract: front page image
(EN)The present disclosure relates to certain compounds having binding affinity for Ku, and uses thereof. Specifically, the present disclosure relates to the use of Ku inhibitors as described herein in site-specific genome engineering technologies, including but not limited to CRISPR/Cas9, Zinc finger nuclease (ZFN), Transcription activator-like effector nuclease (TALEN), and meganuclease. The present disclosure also relates to kits useful for site-specific genome engineering that include at least one compound as described herein.
(FR)L'invention concerne certains composés présentant une affinité de liaison pour Ku, ainsi que leurs utilisations. L'invention concerne en particulier l'utilisation d'inhibiteurs de Ku, tels qu'ici décrits, dans des technologies d'ingénierie génomique propre au site, comprenant entre autres CRISPR/Cas9, une nucléase à doigt de zinc (ZFN), une nucléase effectrice de type activateur de transcription (TALEN) et une méganucléase. L'invention concerne également des kits utiles dans l'ingénierie génomique propre au site, comprennant au moins un composé tel que défini dans l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)