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1. (WO2017205465) ANTIBODIES AND METHODS OF MAKING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/205465 International Application No.: PCT/US2017/034175
Publication Date: 30.11.2017 International Filing Date: 24.05.2017
IPC:
C07K 16/28 (2006.01) ,C07K 16/18 (2006.01) ,A61K 39/395 (2006.01) ,C12N 15/09 (2006.01) ,C12N 15/63 (2006.01)
Applicants: GRISWOLD, Karl, Edwin[US/US]; US
BAILEY-KELLOGG, Chris[US/US]; US
CHOI, Yoonjoo[KR/KR]; KR
Inventors: GRISWOLD, Karl, Edwin; US
BAILEY-KELLOGG, Chris; US
CHOI, Yoonjoo; KR
Agent: TRINQUE, Brian C.; US
BARTON, Steven, K.; US
ANIS, Hissan; US
TRINQUE, Brian, C.; US
ALTER, Scott; US
Priority Data:
62/340,98524.05.2016US
Title (EN) ANTIBODIES AND METHODS OF MAKING SAME
(FR) ANTICORPS ET LEURS PROCÉDÉS DE PRODUCTION
Abstract:
(EN) Provided are variants of a chimeric anti-EGFR antibody. In various embodiments, the variants exhibit substantially improved thermostabilities and/or substantially higher levels of humanness, while retaining binding affinity near the parental level. The consistently high quality of the turnkey CoDAH designs, over a whole panel of variants, suggests that a computationally-directed approach encapsulates key determinants of antibody structure and function.
(FR) Cette invention concerne des variants d'un anticorps chimérique anti-EGFR. Dans divers modes de réalisation, les variants présentent des thermostabilités sensiblement améliorées et/ou des niveaux sensiblement supérieurs d'humanité, tout en conservant une affinité de liaison proche du niveau parental. La qualité constamment élevée des modèles CoDAH de dinde sur un ensemble complet de variants suggère qu'une approche dirigée par ordinateur encapsule les déterminants clés de la structure et de la fonction de l'anticorps.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)