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1. (WO2017205389) IMPROVED THERAPEUTIC INDEX OF ANTI-IMMUNE CHECKPOINT INHIBITORS USING COMBINATION THERAPY COMPRISING A PHY906 EXTRACT, A SCUTELLARIA BAICALENSIS GEORGI (S) EXTRACT OR A COMPOUND FROM SUCH EXTRACTS
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Pub. No.: WO/2017/205389 International Application No.: PCT/US2017/034025
Publication Date: 30.11.2017 International Filing Date: 23.05.2017
IPC:
A61K 31/194 (2006.01) ,A61K 31/282 (2006.01) ,A61K 31/454 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
194
having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
282
Platinum compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
454
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
Applicants:
YALE UNIVERSITY [US/US]; Two Whitney Avenue New Haven, Connecticut 06511, US
Inventors:
CHENG, Yung-Chi; US
CHEN, Lieping; US
Agent:
DOYLE, Kathryn; US
LANDRY, Brian R.; US
SILVA, Domingos J.; US
SIMPSON, Mark D.; US
MANAS, Michael; US
DRISCOLL, Stephen J.; US
EDDE, Chantal; US
CROTTY, Justin; US
Priority Data:
62/340,16423.05.2016US
Title (EN) IMPROVED THERAPEUTIC INDEX OF ANTI-IMMUNE CHECKPOINT INHIBITORS USING COMBINATION THERAPY COMPRISING A PHY906 EXTRACT, A SCUTELLARIA BAICALENSIS GEORGI (S) EXTRACT OR A COMPOUND FROM SUCH EXTRACTS
(FR) AMÉLIORATION DE L'INDICE THÉRAPEUTIQUE D'INHIBITEURS DES POINTS DE CONTRÔLE ANTI-IMMUNITAIRE PAR UTILISATION D'UN TRAITEMENT D'ASSOCIATION COMPRENANT UN EXTRAIT DE PHY906, UN EXTRAIT DE SCUTELLARIA BAICALENSIS GEORGI (S) OU UN COMPOSÉ PROVENANT DE CES EXTRAITS
Abstract:
(EN) The present invention provides a method of treating melanoma and other cancers in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of an herbal extract of PHY906 or Scutellaria baicalensis, a fraction thereof or any active chemical present in the herbal extract or fraction thereof, and one or more immune checkpoint inhibitors. In certain embodiments, the method further comprises administering at least one herbal extract, a fraction thereof or any active chemical present in the herbal extract or fraction thereof, of at least one herb selected from the group consisting of Glycyrrhiza uralensis, Paeonia lactiflora, and Ziziphus jujuba. The methods of the invention are useful for treating cancer such as melanoma, non-small cell lung cancer, renal cell carcinoma, liver cancer, colon cancer, urothelial bladder cancer and pancreatic cancer. In certain embodiments, administration of the herbal extracts of the invention counteract one or more gastrointestinal side effects of the immune checkpoint inhibitors and/or increase their therapeutic index against cancer.
(FR) La présente invention concerne une méthode de traitement du mélanome et d'autres cancers chez un patient, la méthode comprenant l'administration au patient le nécessitant d'une quantité thérapeutiquement efficace d'un extrait végétal de PHY906 ou de Scutellaria baicalensis, d'une fraction de celui-ci, ou de toute substance chimique active présente dans l'extrait végétal ou la fraction de celui-ci, ainsi que d'un ou de plusieurs inhibiteurs des points de contrôle immunitaire. Dans certains modes de réalisation, la méthode comprend en outre l'administration d'au moins un extrait végétal, d'une fraction de celui-ci ou de toute substance chimique active présente dans l'extrait végétal ou la fraction de celui-ci, d'au moins une plante choisie dans le groupe constitué par Glycyrrhiza uralensis, Paeonia lactiflora et Ziziphus jujuba. Les méthodes selon l'invention sont utiles pour traiter des cancers tels que le mélanome, le cancer du poumon non à petites cellules, l'adénocarcinome rénal, le cancer du foie, le cancer du côlon, le cancer de la vessie de type cancer urothélial et le cancer du pancréas. Dans certains modes de réalisation, l'administration des extraits végétaux de l'invention s'oppose à un ou plusieurs des effets indésirables gastro-intestinaux des inhibiteurs des points de contrôle immunitaire et/ou augmente leur indice thérapeutique contre le cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)