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1. (WO2017204510) PHARMACEUTICAL COMPOSITION CONTAINING C-METHYLROTENOID-BASED COMPOUND FOR PREVENTING OR TREATING VASCULAR INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/204510    International Application No.:    PCT/KR2017/005286
Publication Date: 30.11.2017 International Filing Date: 22.05.2017
IPC:
C07D 493/04 (2006.01), A61K 31/35 (2006.01), A61K 31/352 (2006.01), A61K 35/583 (2015.01)
Applicants: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 80, Daehak-ro, Buk-gu, Daegu 41566 (KR)
Inventors: SONG, Kyung-Sik; (KR).
BAE, Jong-Sup; (KR).
LEE, Taeho; (KR).
YANG, Eun-Ju; (KR)
Agent: LEE, Myoung-Jin; (KR)
Priority Data:
10-2016-0062873 23.05.2016 KR
Title (EN) PHARMACEUTICAL COMPOSITION CONTAINING C-METHYLROTENOID-BASED COMPOUND FOR PREVENTING OR TREATING VASCULAR INFLAMMATORY DISEASES
(FR) COMPOSITION PHARMACEUTIQUE CONTENANT UN COMPOSÉ À BASE DE C-MÉTHYLROTÉNOÏDE POUR PRÉVENIR OU TRAITER DES MALADIES INFLAMMATOIRES VASCULAIRES
(KO) C-메틸로테노이드계 화합물을 함유하는 혈관염증질환의 예방 또는 치료용 약학적 조성물
Abstract: front page image
(EN)The present invention relates to a pharmaceutical composition for preventing and treating vascular inflammatory diseases, the composition containing a C-methylrotenoid compound for inhibiting an HMGB1-induced proinflammatory reaction. It was specifically confirmed that the HMGB1-induced proinflammatory reaction was inhibited through the C-methylrotenoid compound according to the present invention, and therefore, the present invention can be effectively used for the prevention and treatment of vascular inflammatory diseases, such as sepsis and septic shock.
(FR)La présente invention concerne une composition pharmaceutique pour prévenir et traiter des maladies inflammatoires vasculaires, la composition contenant un composé C-méthylroténoïde pour inhiber une réaction pro-inflammatoire induite par HMGB1. Il a été spécifiquement confirmé que la réaction pro-inflammatoire induite par HMGB1 était inhibée par l'intermédiaire du composé C-méthylroténoïde selon la présente invention, et par conséquent, la présente invention peut être efficacement utilisée pour la prévention et le traitement de maladies inflammatoires vasculaires, comme la septicémie et le choc septique.
(KO)본 발명은 HMGB1으로 유도된 전염증 반응 억제하는 C-메틸로테노이드 화합물을 함유하는 혈관염증질환의 예방 및 치료용 약학적 조성물 등에 관한 것이다. 본 발명에 따른 C-메틸로테노이드 화합물을 통해 HMGB1으로 유도된 전염증 반응 억제를 구체적으로 확인하였는바, 본 발명은 패혈증 및 패혈성 쇼크와 같은 혈관염증질환의 예방 및 치료에 효과적으로 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)